Which action should be taken to open the 'University Registration' database with exclusive access?

To open the 'University Registration' database with exclusive access, the correct action is to click the arrow on the 'Open' button and select 'Open Exclusive'. This option is specifically designed to allow a user to access the database in a mode where no other users can access it simultaneously. This is essential when changes need to be made to the structure or data of the database without interference from others, ensuring data integrity and preventing conflicts.

This method is recognized in database management systems as a standard way to gain exclusive rights to a file, which is critical in situations where one needs to perform tasks that require the database to be locked to all other users. It helps to prevent accidental data loss or corruption that can occur in multi-user environments.

The other options, while they involve accessing the database in some form, do not provide the specific functionality required to obtain exclusive access. For instance, selecting 'Open' without the exclusive option would allow other users access simultaneously, which defeats the purpose of needing exclusive access. Similarly, right-clicking the file may offer different open options, but 'Open Exclusive' would not typically be among them, and clicking 'Save' would not relate to opening the database at all.